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There are several matches for 'serine/threonine protein kinase'.
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3412 matches
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organism
protein
1)
Homo sapiens
STK16 - Serine/threonine-protein
kinase
16; Membrane-associated
protein
kinase
that phosphorylates on
serine
and
threonine
residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-
protein
kinase
toward other
proteins
.
[a.k.a. AF203910, ENSP00000386928, BC053998]
2)
Homo sapiens
PRKCI -
Protein
kinase
C iota type; Calcium- and diacylglycerol-independent
serine
/
threonine
-
protein
kinase
that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta
protein
-induced apoptosis by interrupting cell death process [...]
[a.k.a. 3ZH8, 6ILZ, ENST00000295797]
3)
Homo sapiens
TTK - Dual specificity
protein
kinase
TTK; Phosphorylates
proteins
on
serine
,
threonine
, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
[a.k.a. MPS1L1, NP_001160163, ENST00000502580]
4)
Homo sapiens
PRKG1 - cGMP-dependent
protein
kinase
1; Serine/threonine
protein
kinase
that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates
serines
and
threonines
on many cellular
proteins
. Numerous
protein
targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types.
Proteins
that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...]
[a.k.a. NM_006258.4, R-HSA-162582, CCDS7244]
5)
Homo sapiens
STRAP -
Serine
-
threonine
kinase
receptor-associated
protein
; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm
proteins
SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric
protein
ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm
proteins
SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICl [...]
[a.k.a. R-HSA-170834, B2R5S5, R-HSA-162582]
6)
Homo sapiens
RIPK1 - Receptor-interacting serine/threonine-protein
kinase
1;
Serine
-
threonine
kinase
which is a key regulator of both cell death and cell survival. Exhibits
kinase
activity- dependent functions that trigger cell death and
kinase
-independent scaffold functions regulating inflammatory signaling and cell survival. Initiates ripoptocide which describes cell death that is dependent on RIPK1, be it apoptosis or necroptosis. Upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold
protein
promoting cell survival, [...]
[a.k.a. R-HSA-2562578, CH471087, R-HSA-5357786]
7)
Homo sapiens
ILK - Integrin-linked
protein
kinase
; Receptor-proximal
protein
kinase
regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion
protein
part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on
serine
and
threonine
residues, but also AKT1 and GSK3B.
[a.k.a. ENSP00000432617, A0A087WW45, XP_024304266]
8)
Homo sapiens
PAK4 - Serine/threonine-protein
kinase
PAK 4; Serine/threonine
protein
kinase
that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several
serine
and/or
threonine
residues. Phosphorylates and inactivates the
protein
phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin [...]
[a.k.a. ENSP00000472862, M0R0L9, ENST00000600350]
9)
Homo sapiens
PAK5 - Serine/threonine-protein
kinase
PAK 5; Serine/threonine
protein
kinase
that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several
serine
and/or
threonine
residues. Phosphorylates the proto-oncogene RAF1 and stimulates its
kinase
activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphoryla [...]
[a.k.a. EAX10359.1, CHEMBL4524, PAK5_HUMAN]
10)
Homo sapiens
DYRK3 - Dual specificity tyrosine-phosphorylation-regulated
kinase
3; Dual-specificity
protein
kinase
that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated
kinases
(DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on
serine
and
threonine
residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phospho [...]
[a.k.a. O43781, 2.7.12.1, NM_001004023.1]
11)
Homo sapiens
PAK2 - Serine/threonine-protein
kinase
PAK 2; Serine/threonine
protein
kinase
that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several
serine
and/or
threonine
residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]
[a.k.a. UPI000198CC7A, R-HSA-162582, R-HSA-109581]
12)
Homo sapiens
PAK3 - Serine/threonine-protein
kinase
PAK 3; Serine/threonine
protein
kinase
that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several
serine
and/or
threonine
residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]
[a.k.a. AB102287, BAC80755.1, NM_001324329]
13)
Homo sapiens
NEK9 - Serine/threonine-protein
kinase
Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic
protein
, beta-casein, and BICD2. Phosphorylates histone H3 on
serine
and
threonine
residues and beta-casein on
serine
residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr- 97 respectively.
[a.k.a. R-HSA-69278, ENST00000238616, ENST00000555961.1]
14)
Homo sapiens
CSNK2A3 - Casein
kinase
II subunit alpha 3; Probable catalytic subunit of a constitutively active serine/threonine-protein
kinase
complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated
serine
or
threonine
. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor
protein
, PML. May play a role in the pathogenesis of the lung cancer development and progression.
[a.k.a. Casein kinase II subunit alpha 3, CSNK2A1P, NP_001243615]
15)
Mus musculus
Stk16 - Serine/threonine-protein
kinase
16; Membrane-associated
protein
kinase
that phosphorylates on
serine
and
threonine
residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-
protein
kinase
toward other
proteins
.
[a.k.a. XM_006496462.1, Edpk, Krct]
16)
Mus musculus
Prkci -
Protein
kinase
C iota type; Calcium- and diacylglycerol-independent
serine
/
threonine
-
protein
kinase
that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta
protein
-induced apoptosis by interrupting cell death process [...]
[a.k.a. 4DC2, R-MMU-446728, Prkci-205]
17)
Mus musculus
Prkg1 - cGMP-dependent
protein
kinase
1; Serine/threonine
protein
kinase
that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates
serines
and
threonines
on many cellular
proteins
. Numerous
protein
targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types.
Proteins
that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...]
[a.k.a. R-MMU-1280218, AW125416, XP_006526831.1]
18)
Mus musculus
Nek1 - Serine/threonine-protein
kinase
Nek1; Phosphorylates
serines
and
threonines
, but also appears to possess tyrosine
kinase
activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (By similarity). May be implicated in the control of meiosis. Involved in cilium assembly (By similarity); Belongs to the
protein
kinase
superfamily. NEK Ser/Thr
protein
kinase
family. NIMA subfamily.
[a.k.a. ENSMUST00000034065, Nek1-209, ENSMUST00000140444.7]
19)
Mus musculus
Ttbk1 - Tau-tubulin
kinase
1; Serine/threonine
kinase
which is able to phosphorylate TAU on
serine
,
threonine
and tyrosine residues. Induces aggregation of TAU (By similarity); Belongs to the
protein
kinase
superfamily. CK1 Ser/Thr
protein
kinase
family.
[a.k.a. Tau tubulin kinase, uc008csx.2, UPI0000D8B48F]
20)
Mus musculus
Strap -
Serine
-
threonine
kinase
receptor-associated
protein
; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm
proteins
SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric
protein
ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm
proteins
SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICl [...]
[a.k.a. AK077504, AK152283, ENSMUSG00000030224]
3412 matches
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